Pioneer at home with computer technology, one at end of line (8)
I believe the answer is:
initiate
'pioneer' is the definition.
('initiate' can be a synonym of 'pioneer')
'at home with computer technology one at end of line' is the wordplay.
'at home' becomes 'in' ('in' can be similar in meaning to 'at home').
'with' is a charade indicator (letters next to each other).
'computer technology' becomes 'it' (I've seen this in other clues).
'one' becomes 'i' (Roman numeral**).
'end of' says to take the final letters.
The final letter of 'line' is 'e'.
'in'+'it'+'i'+'at'+'e'='INITIATE'
(Other definitions for initiate that I've seen before include "Inaugurate, set in motion" , "Make something begin" , "Cause (process) to begin" , "Bring up a topic or prepare the way for" , "Start (something)" .)