Pixy has a problem! Suffocation! (8)
I believe the answer is:
asphyxia
'suffocation' is the definition.
(I've seen this before)
'pixy has a problem' is the wordplay.
'problem' is an anagram indicator.
'pixy'+'has'+'a'='pixyhasa'
'pixyhasa' is an anagram of 'ASPHYXIA'.
(Other definitions for asphyxia that I've seen before include "Suffocation from lack of air in lungs" , "Suffocation, condition caused by lack of oxygen" , "Shortness of breath" , "Oxygen starvation" , "Death by suffocation" .)