Play advertisement put up about "Sign of the Zodiac" (5)
I believe the answer is:
drama
'play' is the definition.
(I know that play can be written as drama)
'advertisement put up about sign of the zodiac' is the wordplay.
'advertisement' becomes 'ad' (abbreviation).
'put up' says the letters should be written backwards.
'about' means one lot of letters goes inside another.
'sign of the zodiac' becomes 'ram' (Aries the Ram).
'ad' back-to-front is 'da'.
'da' going around 'ram' is 'DRAMA'.
(Other definitions for drama that I've seen before include "Theatrical work" , "Stage play - turmoil" , "Literary genre for the theatre" , "Play; emotional event" , "Literary play" .)