Play from Spike, productive American inspiring us (6,7)
I believe the answer is:
doctor faustus
'play' is the definition.
Both the answer and definition are singular nouns.
Maybe there's an association between them I don't understand?
'spike productive american inspiring us' is the wordplay.
'spike' becomes 'doctor' (doctor can mean to spike or adulterate).
'productive american inspiring us' becomes 'faustus' (I can't explain this - if you can you should give a lot more credence to this answer).
'doctor'+'faustus'='DOCTOR FAUSTUS'
'from' acts as a link.
Can you help me to learn more?
(Another definition for doctor faustus that I've seen is " Play by Christopher Marlowe".)