Playing harmonicas, lacking no appeal (8)
I believe the answer is:
charisma
'appeal' is the definition.
(I've seen this before)
'playing harmonicas lacking no' is the wordplay.
'playing' indicates an anagram.
'lacking' suggests deleting specific letters.
'harmonicas' with 'no' removed is 'harmicas'.
'harmicas' is an anagram of 'CHARISMA'.
(Other definitions for charisma that I've seen before include "magnetic quality" , "Ability to inspire people" , "divine power" , "Glamour" , "divinely conferred talent?" .)