Playing too with Pat Murphy (6)
I believe the answer is:
potato
'murphy' is the definition.
(synonyms)
'playing too with pat' is the wordplay.
'playing' is an anagram indicator.
'with' means one lot of letters go next to another.
'too' after 'pat' is 'pattoo'.
'pattoo' anagrammed gives 'POTATO'.
(Other definitions for potato that I've seen before include "Root crop" , "Murphy (informal)" , "French wine region" , "Raleigh brought it from America" , "The humble spud" .)