Playing upon a mine produces complaint (9)
I believe the answer is:
pneumonia
'complaint' is the definition.
(pneumonia is a kind of disease)
'playing upon a mine' is the wordplay.
'playing' is an anagram indicator.
'upon'+'a'+'mine'='uponamine'
'uponamine' with letters rearranged gives 'PNEUMONIA'.
'produces' is the link.
(Other definitions for pneumonia that I've seen before include "Inflammation of the lung" , "Piano menu? (anag)" , "ailment" , "Inflammation of the lungs" , "complaint" .)