Poet takes off (5)
I believe the answer is:
keats
'poet' is the definition.
(John Keats)
'takes off' is the wordplay.
'off' indicates anagramming the letters.
'takes' is an anagram of 'KEATS'.
(Other definitions for keats that I've seen before include "Early 19th century poet" , "Author of Endymion and Ode to a Nightingale" , "Ode to Autumn poet" , "One of two born together" , "John -, Endymion poet" .)