Poisonous alkaloid made into nice mixture (8)
I believe the answer is:
nicotine
'poisonous alkaloid' is the definition.
'nicotine' can be an answer for 'alkaloid' (nicotine is a kind of alkaloid). I'm not sure about the 'poisonous' bit.
'into nice mixture' is the wordplay.
'mixture' is an anagram indicator.
'into'+'nice'='intonice'
'intonice' anagrammed gives 'NICOTINE'.
'made' acts as a link.
Can you help me to learn more?
(Other definitions for nicotine that I've seen before include "Addictive drug" , "Hooker" , "Drug often smoked" , "Once in it (anag)" , "Chemical in cigarette" .)