Poisonous to several, I see (5)
I believe the answer is:
toxic
'poisonous' is the definition.
(similar in meaning)
'to several i see' is the wordplay.
'several i' becomes 'xi' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'see' becomes 'C' (the word for the letter, according to Chambers).
'to'+'xi'+'c'='TOXIC'
Can you help me to learn more?
(Other definitions for toxic that I've seen before include "word describing bad things" , "Harmful - cox it (anag)" , "Poisonous, noxious" , "Deadly - venomous" .)