Poke Italian's toe (5)
I believe the answer is:
digit
'toe' is the definition.
(digit on a foot)
'poke italian's' is the wordplay.
'poke' becomes 'dig' (synonyms).
'italian' becomes 'it' (abbreviation for Italian).
'dig'+'it'='DIGIT'
(Other definitions for digit that I've seen before include "zero, one, two, three, four, five, six, seven, eight, or nine" , "one's given?" , "E.g. toe" , "Finger; number" , "A small number" .)