Poor signs unfortunately in forecast (9)
I believe the answer is:
prognosis
'forecast' is the definition.
(I know that forecast can be written as prognosis)
'poor signs unfortunately' is the wordplay.
'unfortunately' indicates anagramming the letters (a bad or unfortunate spelling).
'poor'+'signs'='poorsigns'
'poorsigns' anagrammed gives 'PROGNOSIS'.
'in' acts as a link.
(Other definitions for prognosis that I've seen before include "Medical opinion" , "Prediction as to how something will turn out" , "Medical prediction" , "Forecast, outlook" , "Forecast of course of illness as by doctor" .)