Portrait of animal so original (4,4)
I believe the answer is:
mona lisa
'portrait' is the definition.
(I've seen this before)
'animal so original' is the wordplay.
'original' indicates anagramming the letters.
'animal'+'so'='animalso'
'animalso' with letters rearranged gives 'MONA LISA'.
'of' is the link.
(Other definitions for mona lisa that I've seen before include "Famous painting of enigmatic woman by daVinci" , "Leonardo da Vinci's painting of enigmatic woman" , "Fertiliser from seabirds" , "depicted, in the Louvre" , "Picture" .)