Possessed of humour and a head of hair (4)
I believe the answer is:
with
'possessed of humour and a head of hair' is the definition.
I can't judge whether this defines the answer.
'humour and a head of hair' is the wordplay.
'humour' becomes 'wit' (synonyms).
'and' means one lot of letters go next to another.
'a head of' says to take the initial letters.
The initial letter of 'hair' is 'h'.
'wit'+'h'='WITH'
Can you help me to learn more?
(Other definitions for with that I've seen before include "understanding" , "Characterised by" , "Among" , "Accompanying" , "In spite of" .)