Pounds invested in women’s area in New York district (6)
I believe the answer is:
harlem
'new york district' is the definition.
'pounds invested in women's area' is the wordplay.
'pounds' becomes 'l' (L can represent the monetary pound).
'invested in' means one lot of letters goes inside another.
'women's area' becomes 'harem' (historical area of a Muslim household for women).
'l' placed within 'harem' is 'HARLEM'.
'in' acts as a link.
(Other definitions for harlem that I've seen before include "New York neighbourhood" , "NY community" , "Part of New York City" , "Area of New York city" , "some of the Big Apple" .)