Practised with beer, holding bottle opener (4)
I believe the answer is:
able
'practised' is the definition.
(I've seen this before)
'beer holding bottle opener' is the wordplay.
'beer' becomes 'ale' (I've seen this before).
'holding' means one lot of letters goes inside another.
'opener' indicates taking the first letters.
The first letter of 'bottle' is 'b'.
'ale' placed around 'b' is 'ABLE'.
'with' acts as a link.
(Other definitions for able that I've seen before include "Competent and equipped" , "Competent and fit, like sailor" , "Having the necessary capacity (to do something)" , "Having the power, skill or means (to do something)" , "As capable as a mariner" .)