Praise article on socially acceptable male drug (8)
I believe the answer is:
laudanum
'drug' is the definition.
(laudanum is a kind of drug)
'praise article on socially acceptable male' is the wordplay.
'praise' becomes 'laud' (lauding is a kind of praising**).
'article' becomes 'an' (indefinite article).
'on' says to put letters next to each other.
'socially acceptable' becomes 'u'.
'male' becomes 'm' (common abbreviation).
'laud'+'an'+'u'+'m'='LAUDANUM'
(Other definitions for laudanum that I've seen before include "Formerly respectable drug" , "Tincture of opium" , "Opium-based drug" , "Narcotic of choice in old novels" , "Former painkiller" .)