Precise study involving trouble (4,2)
I believe the answer is:
dead-on
'precise' is the definition.
(synonyms)
'study involving trouble' is the wordplay.
'study' becomes 'den' (term for a study or office).
'involving' is an insertion indicator.
'trouble' becomes 'ado' (both can mean bother or commotion).
'den' going around 'ado' is 'DEAD-ON'.
(Another definition for dead-on that I've seen is " Exactly right".)
I've seen this clue in The Times.
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