Predict death will come after strong wine (7)
I believe the answer is:
'predict' is the definition.
'death will come after strong wine' is the wordplay.
'death' becomes 'end' (synonyms).
'will come after' says to put letters next to each other.
'strong wine' becomes 'port' (type of strong wine).
'end' after 'port' is 'PORTEND'.
(Other definitions for portend that I've seen before include "Give warning", "Betoken; presage", "forecast", "Be a sign of something to come", "Omen".)