Prefix with natal (3)
I believe the answer is:
neo
'prefix with natal' is the definition.
(I've seen this in another clue)
This is the entire clue.
(Other definitions for neo that I've seen before include "Prefix meaning new - try one" , "Prefix donating new" , "Prefix meaning new of modern form of" , "language" , "Hero of The Matrix films; new (prefix)" .)