Presumably nothing left in safe (3,5)
I believe the answer is:
all right
'safe' is the definition.
(all right means safe or secure)
'presumably nothing left' is the wordplay.
I cannot really see how this works, but
'left' could be 'al' (I've seen this in other clues) and 'al' is found within the answer.
This may be the basis of the clue (or it may be nonsense).
'in' acts as a link.
Can you help me to learn more?
(Other definitions for all right that I've seen before include "Completely one-sided" , "Agreed" , "What's clearly acceptable" , "Okay" , "no mistake!" .)