Prickling sensation (6)
I believe the answer is:
tingle
'prickling sensation' is the definition.
(I've seen this before)
This is all the clue.
(Other definitions for tingle that I've seen before include "Feel slight stinging sensation" , "Throb" , "Shiver down the spine?" , "Suffer pins and needles" , "Slight prickling sensation" .)