Priest originally taking grain round large chamber (9)
I believe the answer is:
ventricle
'chamber' is the definition.
(I know that ventricle is a type of chamber)
'priest originally taking grain round large' is the wordplay.
'priest' becomes 'ven' (abbreviation for The Venerable).
'originally taking grain' becomes 'trice' (I can't justify this - if you can you should believe this answer much more).
'round' means one lot of letters goes inside another.
'large' becomes 'L' (eg in clothes sizes).
'trice' enclosing 'l' is 'tricle'.
'ven'+'tricle'='VENTRICLE'
Can you help me to learn more?
(Other definitions for ventricle that I've seen before include "One of four heart chambers" , "bloody pump!" , "Chamber in organ of body - the heart has two" , "Heart cavity that pumps blood to arteries" .)