Principal sets up computers (10)
I believe the answer is:
mainframes
'computers' is the definition.
(mainframe is a kind of computer)
'principal sets up' is the wordplay.
'principal' becomes 'main' (I've seen this before).
'sets up' becomes 'frames' ('frame' can be a synonym of 'set up'**).
'main'+'frames'='MAINFRAMES'
I've seen this clue in The Telegraph.
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