Problems for viewers in street, of course (5)
I believe the answer is:
styes
'problems for viewers' is the definition.
('eyes' might whimsically be called 'viewers')
'street of course' is the wordplay.
'street' becomes 'st'.
'of course' becomes 'yes' (I've seen this before).
'st'+'yes'='STYES'
'in' is the link.
(Other definitions for styes that I've seen before include "Eye troubles" , "Problems seeing" , "gatherings" , "Eye infections" , "Eyesores" .)