Problems with paper handkerchiefs wiping face (6)
I believe the answer is:
issues
'problems' is the definition.
(I've seen this before)
'paper handkerchiefs wiping face' is the wordplay.
'paper handkerchiefs' becomes 'tissues' (I've seen this before).
'wiping face' means to remove the first letter (the face of the word is removed).
'tissues' with its first letter removed is 'ISSUES'.
'with' acts as a link.
(Other definitions for issues that I've seen before include "Comes out of or publishes" , "Personal problems" , "Flows out" , "Brings out a publication" , "Editions or important questions" .)