Produce offspring (5)
(Other definitions for issue that I've seen before include "Susie (anag.)" , "Continent" , "Put out; result" , "Subject of debate" , "particular edition of magazine?" .)
'produce offspring' is the definition.
(I've seen this in another clue)
This is all the clue.
(Other definitions for spawn that I've seen before include "Generate; fish eggs" , "offspring" , "Give rise to; fish egg" , "Eggs of fish, frogs, etc" , "(Of fish) release eggs" .)