Profane, defile (9)
I believe the answer is:
desecrate
I believe this is a double definition.
'profane' is the first definition.
(I know that profane can be written as desecrate)
'defile' is the second definition.
(thesaurus)
(Other definitions for desecrate that I've seen before include "Spoil" , "Violate the sacred" , "Secreted a means to treat something sacred with disrespect" , "Profane" , "Treat (something sacred) with great disrespect" .)