Pronounced defect in Botticelli's painting (4)
I believe the answer is:
lisp
'pronounced defect' is the definition.
Although both the answer and definition are singular nouns, I don't see how they can define each other.
'in botticelli's painting' is the wordplay.
'in' indicates the answer is hidden within the clue.
'LISP' is hidden in the letters of 'botticellis painting'.
Can you help me to learn more?
(Other definitions for lisp that I've seen before include "Non-standard pronunciation" , "Slight speech impediment" , "Talk like thith" , "Speak with defective sibilants" , "Be unable to pronounce S" .)