Prosper initially over in lodge (2,4)
I believe the answer is:
do well
'prosper' is the definition.
(thesaurus)
'initially over in lodge' is the wordplay.
'initially' suggests taking the first letters.
'in' is an insertion indicator.
'lodge' becomes 'dwell' (both can mean to inhabit a place).
The initial letter of 'over' is 'o'.
'o' going into 'dwell' is 'DO WELL'.
(Other definitions for do well that I've seen before include "boom" , "Flourish" .)