Protect home with safe (6)
I believe the answer is:
insure
'protect' is the definition.
(insuring is a kind of protecting)
'home with safe' is the wordplay.
'home' becomes 'in' ('he's home' can mean 'he's in').
'with' says to put letters next to each other.
'safe' becomes 'sure' (I've seen this before).
'in'+'sure'='INSURE'
(Other definitions for insure that I've seen before include "Take out cover" , "Guarantee against loss" , "Protect against possible loss" , "Take out a policy" , "Make certain" .)