Provided, in general, four (5)
I believe the answer is:
given
'provided' is the definition.
(I've seen this before)
'in general four' is the wordplay.
'in' is an insertion indicator.
'general' becomes 'gen'.
'four' becomes 'IV' (Roman numerals).
'gen' enclosing 'iv' is 'GIVEN'.
(Other definitions for given that I've seen before include "Known fact" , "Bestowed" , "Lent?" , "Specified - granted" , "Donated" .)