Provoke, with "up" (4)
I believe the answer is:
rile
(Other definitions for rile that I've seen before include "Lire (anag)" , "Provoke" , "'Vex, irritate (4)'" , "Irk" , "Get up nose of" .)
I believe the answer is:
rile
(Other definitions for rile that I've seen before include "Lire (anag)" , "Provoke" , "'Vex, irritate (4)'" , "Irk" , "Get up nose of" .)