Puff, no longer fit? (6)
I believe the answer is:
exhale
'puff' is the definition.
(I've seen this before)
'no longer fit?' is the wordplay.
'no longer' becomes 'ex'.
'fit?' becomes 'hale' (both can mean healthy).
'ex'+'hale'='EXHALE'
(Other definitions for exhale that I've seen before include "Discharge" , "Breathe out" , "Expel air from the lungs" , "Emit breath" , "send forth wind" .)