Punch copper with two females (4)
I believe the answer is:
cuff
'punch' is the definition.
(thesaurus)
'copper with two females' is the wordplay.
'copper' becomes 'Cu' (chemical symbol).
'with' says to put letters next to each other.
'two females' becomes 'ff'.
'cu'+'ff'='CUFF'
(Other definitions for cuff that I've seen before include "Blow - it's on shirt!" , "minor assault" , "Sleeve ending" , "clout" , "Light blow with the open hand" .)