Put old record in missile and take off (6)
I believe the answer is:
depart
'take off' is the definition.
(synonyms)
'put old record in missile' is the wordplay.
I cannot really understand how this works, but
'record' could be 'ep' (abbreviation for extended play record) and 'ep' is present in the answer.
'missile' could be 'dart' (dart is a kind of missile) and 'dart' is located in the remaining letters.
This accounts for all the letters.
This may be the basis of clue (or it may be nonsense).
'and' acts as a link.
(Other definitions for depart that I've seen before include "Start out" , "21" , "Take one's leave, go" , "Leave, vanish" , "Make an exit" .)