Puts up with depression sending son to the south (5)

I believe the answer is:

lumps

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'puts up with' is the definition.
(lump can mean to bear or tolerate)

I can't explain the remainder of the clue.

(Other definitions for lumps that I've seen before include "Clods or swellings" , "Compact masses" , "Chunks" , "Puts up with" .)

I've seen this clue in The Telegraph.

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