Quarrel makes tame designer wild (12)
I believe the answer is:
disagreement
'quarrel' is the definition.
(I've seen this before)
'tame designer wild' is the wordplay.
'wild' indicates an anagram.
'tame'+'designer'='tamedesigner'
'tamedesigner' anagrammed gives 'DISAGREEMENT'.
'makes' is the link.
(Other definitions for disagreement that I've seen before include "dispute" , "Argument" , "Contretemps" , "Difference of opinion" , "Quarrel" .)