Queen of Castile made her name as a libel negotiator (8)
I believe the answer is:
isabella
'queen' is the definition.
(I have seen 'Spanish Queen ' mean 'isabella' so perhaps 'queen' could also mean 'isabella')
'castile made her name as a libel negotiator' is the wordplay.
'as a libel' can be anagrammed to 'ISABELLA'.
Though, I'm not clear how the anagram is indicated.
'of' acts as a link.
Can you help me to learn more?
(Other definitions for isabella that I've seen before include "Woman" , "drab colour" , "Wife of Edward II" , "Ferdinand V's queen" , "Wife of Ferdinand II of Aragon" .)