Queen to take over with no sign of affection (4)
I believe the answer is:
anne
'queen' is the definition.
(I've seen this before)
'take over with no sign of affection' is the wordplay.
'take over' becomes 'annex' (annexing is a kind of taking over).
'with no' is a deletion indicator.
'sign of affection' becomes 'x' (used to represent a kiss).
'annex' with 'x' removed is 'ANNE'.
'to' is the link.
(Other definitions for anne that I've seen before include "English queen" , "--- Elliot, later Wentworth (J. Austen)" , "Last Stuart monarch, d. 1714" , "Queen seventeen hundred and two to seventeen fourteen" , "Shakespeare's wife's name" .)