Question framed by a leading lady? (5,2,1,4)

I believe the answer is:
whats in a name
'question framed by a leading lady?' is the definition.
I don't know anything about this answer so I cannot judge whether it can be defined by this definition.
'question framed by a leading lady?' is the wordplay.
I cannot really understand how this works, but
'question' could be 'what' (what is a question word) and 'what' is present in the answer.
'a' could be 'an' and 'an' is located in the answer.
'leading' could be 'in' (in government) and 'in' is found in the answer.
'lady?' could be 'sam' and 'sam' is found in the remaining letters.
A single letter 'e' remains which might be clued in a way I don't understand.
This may be the basis of the clue (or it may be nonsense).
Can you help me to learn more?