Question large cry (4)
I believe the answer is:
howl
'cry' is the definition.
(howl is a kind of cry)
'question large' is the wordplay.
'question' becomes 'how' (I've seen this in other clues).
'large' becomes 'l'.
'how'+'l'='HOWL'
(Other definitions for howl that I've seen before include "Plaintive wolf cry" , "Long cry of pain" , "Cry (with rage or laughter)" , "Long, loud, emotional cry" , "Long, loud, emotional utterance" .)