Question large cry (4)
I believe the answer is:
howl
'cry' is the definition.
(to howl is to cry out)
'question large' is the wordplay.
'question' becomes 'how' (how is a question word).
'large' becomes 'L' (eg in clothes sizes).
'how'+'l'='HOWL'
(Other definitions for howl that I've seen before include "Plaintive wolf cry" , "Long cry of pain" , "Cry (with rage or laughter)" , "Long, loud, emotional cry" , "Long, loud, emotional utterance" .)