Quick to make an issue out of nothing (4)
I believe the answer is:
soon
'quick' is the definition.
(thesaurus)
'an issue out of nothing' is the wordplay.
'an issue' becomes 'son' (issue can mean someone's offspring).
'out of' means one lot of letters goes inside another (some letters on the outside of others).
'nothing' becomes 'O' (O resembles 0).
'son' placed around 'o' is 'SOON'.
'to make' acts as a link.
(Other definitions for soon that I've seen before include "Willingly" , "In a little while" , "Early; readily" , "Early, in a short time" , "Before you can say Jack Robinson" .)