Quits from business, never to return (5)
I believe the answer is:
evens
'quits' is the definition.
(I've seen this before)
'from business never to return' is the wordplay.
'from' indicates a hidden word.
'to return' shows that the letters should be reversed in order.
'sneve' is hidden in the letters of 'business never'.
'sneve' backwards is 'EVENS'.
(Other definitions for evens that I've seen before include "Kind of bet where odds are one to one" , "50-50 chance" , "Kind of betting odds on seven" , "square" , "Odds that win identical sum as the stake" .)