Raise dough — go north (6)
I believe the answer is:
leaven
'raise dough' is the definition.
(I've seen this in another clue)
'go north' is the wordplay.
'go' becomes 'leave' (go can mean to depart or leave).
'north' becomes 'N' (abbreviation).
'leave'+'n'='LEAVEN'
(Other definitions for leaven that I've seen before include "Ferment, raise" , "Something like yeast" , "Substance that makes dough ferment" , "Substance added to dough to make it rise" , "It makes dough rise" .)