Raised in Africa, a significant biblical figure (5)
I believe the answer is:
isaac
'biblical figure' is the definition.
(I've seen this before)
'raised in africa a significant' is the wordplay.
'raised' is a reversal indicator (going up in a down clue).
'in' says the answer is hidden in the clue.
'caasi' is hidden within 'africa a significant'.
'caasi' in reverse letter order is 'ISAAC'.
(Other definitions for isaac that I've seen before include "___ Newton, English physicist, d. 1727" , "Biblical father of twins" , "According to the book, twins' dad" , "Actor Oscar" , "Son of Abraham, offered as a sacrifice to God" .)