Ran off with an artist and ate out (7)
I believe the answer is:
drained
'ran' is the definition.
(draining is a kind of running)
'with an artist and ate out' is the wordplay.
'with' means one lot of letters goes inside another.
'an artist' becomes 'RA' (Royal Academician, member of Royal Academy of Arts).
'and' becomes 'n' (common abbreviation for 'and').
'ate' becomes 'died' (I can't explain this - if you can you should give a lot more credence to this answer).
'out' indicates putting letters inside.
'n' going within 'died' is 'dined'.
'ra' placed within 'dined' is 'DRAINED'.
'off' acts as a link.
Can you help me to learn more?
(Other definitions for drained that I've seen before include "Exhausted" , "Emptied of liquid" , "Tired" , "spent" , "Deprived of strength" .)