Ran quite an operation in period of isolation (10)
I believe the answer is:
quarantine
'period of isolation' is the definition.
(I've seen this before)
'ran quite an operation' is the wordplay.
'ran quite an' can be anagrammed to 'QUARANTINE'.
But, I'm not clear how this is indicated.
'in' is the link.
Can you help me to learn more?
(Other definitions for quarantine that I've seen before include "Precautionary seclusion" , "Isolate (to prevent spread of disease)" , "separate from others" , "Compulsory isolation to prevent spread of disease" , "solitary confinement" .)