Range and directions (5)
I believe the answer is:
andes
'range' is the definition.
(South American mountain range)
'and directions' is the wordplay.
'directions' becomes 'Es' (east and south - two directions).
'and'+'es'='ANDES'
(Other definitions for andes that I've seen before include "South American mountain range" , "Great mountains of western S America" , "danes found in mountains" , "Mountains in west" , "The range of llamas?" .)