Rants, seeing no one does business (6)
I believe the answer is:
trades
'does business' is the definition.
(to trade is to do business)
'rants seeing no one' is the wordplay.
'rants' becomes 'tirades' (I've seen this in another clue).
'seeing no' suggests deleting specific letters.
'one' becomes 'i' (Roman numeral).
'tirades' with 'i' taken away is 'TRADES'.
(Other definitions for trades that I've seen before include "will give some folk a living" , "Buys and sells shares" , "Exchanges, buys or sells" , "Occupations" , "Swaps - winds" .)